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pentobarbital will lower the extent or influence of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Solid CYP3A4 inducers may perhaps minimize midostaurin concentrations leading to minimized efficacy.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​�